This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| KCNA1-20-RE | 20 (40 μL) | 200 μL |  |
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| KCNA1-20-OR | 20 (40 μL) | 200 μL |  |
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| KCNA1-20-GO | 20 (40 μL) | 200 μL |  |
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| KCNA1-20-GR | 20 (40 μL) | 200 μL |  |
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| KCNA1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq, Jul 2008]
Gene Symbol : KCNA1
Gene Name : Potassium voltage-gated channel subfamily A member 1
Chromosome : CHR 12: 490,990,6-491,825,5
Locus : 12p13.32
Alt. Genes : ABI2
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