This gene encodes a protein containing a BTB (Broad-complex, tramtrack and bric a brac), also known as a POZ (POxvirus and zinc finger) protein-protein interaction domain. The encoded protein negatively regulates the AP-2 family of transcription factors and the Wnt signaling pathway. A mechanism for the modulation of Wnt signaling has been proposed in which the encoded protein enhances ubiquitination and degradation of the beta-catenin protein. Mutations in this gene have been identified in Scalp-ear-nipple (SEN) syndrome. [provided by RefSeq, May 2017]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| KCTD1-20-RE | 20 (40 μL) | 200 μL |  |
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| KCTD1-20-OR | 20 (40 μL) | 200 μL |  |
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| KCTD1-20-GO | 20 (40 μL) | 200 μL |  |
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| KCTD1-20-GR | 20 (40 μL) | 200 μL |  |
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| KCTD1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a protein containing a BTB (Broad-complex, tramtrack and bric a brac), also known as a POZ (POxvirus and zinc finger) protein-protein interaction domain. The encoded protein negatively regulates the AP-2 family of transcription factors and the Wnt signaling pathway. A mechanism for the modulation of Wnt signaling has been proposed in which the encoded protein enhances ubiquitination and degradation of the beta-catenin protein. Mutations in this gene have been identified in Scalp-ear-nipple (SEN) syndrome. [provided by RefSeq, May 2017]
Gene Symbol : KCTD1
Gene Name : Potassium channel tetramerization domain containing 1
Chromosome : CHR 18: 266,574,00-264,549,09
Locus : 18q11.2
Alt. Genes : ZNF263
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