This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies. [provided by RefSeq, Oct 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| KIF7-20-RE | 20 (40 μL) | 200 μL |  |
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| KIF7-20-OR | 20 (40 μL) | 200 μL |  |
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| KIF7-20-GO | 20 (40 μL) | 200 μL |  |
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| KIF7-20-GR | 20 (40 μL) | 200 μL |  |
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| KIF7-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies. [provided by RefSeq, Oct 2011]
Gene Symbol : KIF7
Gene Name : Kinesin family member 7
Chromosome : CHR 15: 896,630,85-896,279,69
Locus : 15q26.1
Alt. Genes : LRPPRC
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