This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| KLKB1-20-RE | 20 (40 μL) | 200 μL |  |
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| KLKB1-20-OR | 20 (40 μL) | 200 μL |  |
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| KLKB1-20-GO | 20 (40 μL) | 200 μL |  |
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| KLKB1-20-GR | 20 (40 μL) | 200 μL |  |
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| KLKB1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Gene Symbol : KLKB1
Gene Name : Kallikrein B1
Chromosome : CHR 4: 186,215,713-186,258,476
Locus : 4q35.2
Alt. Genes : CHST4
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