This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed. [provided by RefSeq, Dec 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LARS-20-RE | 20 (40 μL) | 200 μL |  |
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| LARS-20-OR | 20 (40 μL) | 200 μL |  |
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| LARS-20-GO | 20 (40 μL) | 200 μL |  |
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| LARS-20-GR | 20 (40 μL) | 200 μL |  |
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| LARS-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed. [provided by RefSeq, Dec 2015]
Gene Symbol : LARS
Gene Name : Leucyl-tRNA synthetase
Chromosome : CHR 5: 146,182,786-146,113,025
Locus : 5q32
Alt. Genes : PREB
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