The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LAT-20-RE | 20 (40 μL) | 200 μL |  |
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| LAT-20-OR | 20 (40 μL) | 200 μL |  |
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| LAT-20-GO | 20 (40 μL) | 200 μL |  |
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| LAT-20-GR | 20 (40 μL) | 200 μL |  |
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| LAT-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Symbol : LAT
Gene Name : Linker for activation of T-cells
Chromosome : CHR 16: 289,848,25-289,907,82
Locus : 16p11.2
Alt. Genes : WASF2
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