This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LATS2-20-RE | 20 (40 μL) | 200 μL |  |
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| LATS2-20-OR | 20 (40 μL) | 200 μL |  |
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| LATS2-20-GO | 20 (40 μL) | 200 μL |  |
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| LATS2-20-GR | 20 (40 μL) | 200 μL |  |
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| LATS2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
Gene Symbol : LATS2
Gene Name : Large tumor suppressor kinase 2
Chromosome : CHR 13: 210,615,82-209,730,35
Locus : 13q12.11
Alt. Genes : KIF20A
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