This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LGI1-20-RE | 20 (40 μL) | 200 μL |  |
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| LGI1-20-OR | 20 (40 μL) | 200 μL |  |
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| LGI1-20-GO | 20 (40 μL) | 200 μL |  |
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| LGI1-20-GR | 20 (40 μL) | 200 μL |  |
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| LGI1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Gene Symbol : LGI1
Gene Name : Leucine rich glioma inactivated 1
Chromosome : CHR 10: 937,577,69-937,981,73
Locus : 10q23.33
Alt. Genes : OPTN
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