The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LIN28B-20-RE | 20 (40 μL) | 200 μL |  |
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| LIN28B-20-OR | 20 (40 μL) | 200 μL |  |
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| LIN28B-20-GO | 20 (40 μL) | 200 μL |  |
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| LIN28B-20-GR | 20 (40 μL) | 200 μL |  |
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| LIN28B-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]
Gene Symbol : LIN28B
Gene Name : Lin-28 homolog B
Chromosome : CHR 6: 104,936,998-105,083,331
Locus : 6q16.3-q21
Alt. Genes : PREB
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