This gene encodes a member of the LMBR1-like membrane protein family. Another member of this protein family has been shown to be a lipocalin transmembrane receptor. A highly conserved, cis-acting regulatory module for the sonic hedgehog gene is located within an intron of this gene. Consequently, disruption of this genic region can alter sonic hedgehog expression and affect limb patterning, but it is not known if this gene functions directly in limb development. Mutations and chromosomal deletions and rearrangements in this genic region are associated with acheiropody and preaxial polydactyly, which likely result from altered sonic hedgehog expression. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LMBR1-20-RE | 20 (40 μL) | 200 μL |  |
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| LMBR1-20-OR | 20 (40 μL) | 200 μL |  |
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| LMBR1-20-GO | 20 (40 μL) | 200 μL |  |
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| LMBR1-20-GR | 20 (40 μL) | 200 μL |  |
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| LMBR1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the LMBR1-like membrane protein family. Another member of this protein family has been shown to be a lipocalin transmembrane receptor. A highly conserved, cis-acting regulatory module for the sonic hedgehog gene is located within an intron of this gene. Consequently, disruption of this genic region can alter sonic hedgehog expression and affect limb patterning, but it is not known if this gene functions directly in limb development. Mutations and chromosomal deletions and rearrangements in this genic region are associated with acheiropody and preaxial polydactyly, which likely result from altered sonic hedgehog expression. [provided by RefSeq, Jul 2008]
Gene Symbol : LMBR1
Gene Name : Limb development membrane protein 1
Chromosome : CHR 7: 156,893,207-156,673,353
Locus : 7q36.3
Alt. Genes : ZNF263
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