This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LMO1-20-RE | 20 (40 μL) | 200 μL |  |
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| LMO1-20-OR | 20 (40 μL) | 200 μL |  |
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| LMO1-20-GO | 20 (40 μL) | 200 μL |  |
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| LMO1-20-GR | 20 (40 μL) | 200 μL |  |
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| LMO1-20-AQ | 20 (40 μL) | 200 μL |  |
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This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012]
Gene Symbol : LMO1
Gene Name : LIM domain only 1
Chromosome : CHR 11: 826,863,4-822,430,3
Locus : 11p15.4
Alt. Genes : TRAP1
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