In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LONP2-20-RE | 20 (40 μL) | 200 μL |  |
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| LONP2-20-OR | 20 (40 μL) | 200 μL |  |
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| LONP2-20-GO | 20 (40 μL) | 200 μL |  |
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| LONP2-20-GR | 20 (40 μL) | 200 μL |  |
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| LONP2-20-AQ | 20 (40 μL) | 200 μL |  |
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In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]
Gene Symbol : LONP2
Gene Name : Lon peptidase 2, peroxisomal
Chromosome : CHR 16: 482,441,66-483,539,78
Locus : 16q12.1
Alt. Genes : RAD50
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