This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LOX-20-RE | 20 (40 μL) | 200 μL |  |
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| LOX-20-OR | 20 (40 μL) | 200 μL |  |
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| LOX-20-GO | 20 (40 μL) | 200 μL |  |
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| LOX-20-GR | 20 (40 μL) | 200 μL |  |
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| LOX-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016]
Gene Symbol : LOX
Gene Name : Lysyl oxidase
Chromosome : CHR 5: 122,078,500-122,063,194
Locus : 5q23.1
Alt. Genes : DNAL4
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