This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LOXL2-20-RE | 20 (40 μL) | 200 μL |  |
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| LOXL2-20-OR | 20 (40 μL) | 200 μL |  |
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| LOXL2-20-GO | 20 (40 μL) | 200 μL |  |
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| LOXL2-20-GR | 20 (40 μL) | 200 μL |  |
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| LOXL2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
Gene Symbol : LOXL2
Gene Name : Lysyl oxidase like 2
Chromosome : CHR 8: 234,042,08-232,968,96
Locus : 8p21.3
Alt. Genes : OPTN
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