The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LRR1-20-RE | 20 (40 μL) | 200 μL |  |
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| LRR1-20-OR | 20 (40 μL) | 200 μL |  |
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| LRR1-20-GO | 20 (40 μL) | 200 μL |  |
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| LRR1-20-GR | 20 (40 μL) | 200 μL |  |
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| LRR1-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
Gene Symbol : LRR1
Gene Name : Leucine rich repeat protein 1
Chromosome : CHR 14: 495,986,96-496,146,71
Locus : 14q21.3
Alt. Genes : KIF20A
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