The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LRRFIP2-20-RE | 20 (40 μL) | 200 μL |  |
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| LRRFIP2-20-OR | 20 (40 μL) | 200 μL |  |
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| LRRFIP2-20-GO | 20 (40 μL) | 200 μL |  |
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| LRRFIP2-20-GR | 20 (40 μL) | 200 μL |  |
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| LRRFIP2-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]
Gene Symbol : LRRFIP2
Gene Name : LRR binding FLII interacting protein 2
Chromosome : CHR 3: 371,768,16-370,526,25
Locus : 3p22.2
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