The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LZTS2-20-RE | 20 (40 μL) | 200 μL |  |
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| LZTS2-20-OR | 20 (40 μL) | 200 μL |  |
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| LZTS2-20-GO | 20 (40 μL) | 200 μL |  |
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| LZTS2-20-GR | 20 (40 μL) | 200 μL |  |
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| LZTS2-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Gene Symbol : LZTS2
Gene Name : Leucine zipper tumor suppressor 2
Chromosome : CHR 10: 100,997,064-101,007,835
Locus : 10q24.31
Alt. Genes : LRPPRC
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