The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MANF-20-RE | 20 (40 μL) | 200 μL |  |
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| MANF-20-OR | 20 (40 μL) | 200 μL |  |
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| MANF-20-GO | 20 (40 μL) | 200 μL |  |
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| MANF-20-GR | 20 (40 μL) | 200 μL |  |
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| MANF-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]
Gene Symbol : MANF
Gene Name : Mesencephalic astrocyte derived neurotrophic factor
Chromosome : CHR 3: 513,852,36-513,893,96
Locus : 3p21.2
Alt. Genes : LRPPRC
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