The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MAP3K7-20-RE | 20 (40 μL) | 200 μL |  |
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| MAP3K7-20-OR | 20 (40 μL) | 200 μL |  |
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| MAP3K7-20-GO | 20 (40 μL) | 200 μL |  |
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| MAP3K7-20-GR | 20 (40 μL) | 200 μL |  |
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| MAP3K7-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Symbol : MAP3K7
Gene Name : Mitogen-activated protein kinase kinase kinase 7
Chromosome : CHR 6: 905,873,00-905,135,72
Locus : 6q15
Alt. Genes : SGK2
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