The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MAP4K2-20-RE | 20 (40 μL) | 200 μL |  |
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| MAP4K2-20-OR | 20 (40 μL) | 200 μL |  |
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| MAP4K2-20-GO | 20 (40 μL) | 200 μL |  |
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| MAP4K2-20-GR | 20 (40 μL) | 200 μL |  |
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| MAP4K2-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Gene Symbol : MAP4K2
Gene Name : Mitogen-activated protein kinase kinase kinase kinase 2
Chromosome : CHR 11: 648,032,53-647,869,13
Locus : 11q13.1
Alt. Genes : TRIM28
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