The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MAP4K4-20-RE | 20 (40 μL) | 200 μL |  |
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| MAP4K4-20-OR | 20 (40 μL) | 200 μL |  |
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| MAP4K4-20-GO | 20 (40 μL) | 200 μL |  |
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| MAP4K4-20-GR | 20 (40 μL) | 200 μL |  |
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| MAP4K4-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Symbol : MAP4K4
Gene Name : Mitogen-activated protein kinase kinase kinase kinase 4
Chromosome : CHR 2: 101,697,702-101,894,689
Locus : 2q11.2
Alt. Genes : ZNF263
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