The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MAPKAPK5-20-RE | 20 (40 μL) | 200 μL |  |
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| MAPKAPK5-20-OR | 20 (40 μL) | 200 μL |  |
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| MAPKAPK5-20-GO | 20 (40 μL) | 200 μL |  |
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| MAPKAPK5-20-GR | 20 (40 μL) | 200 μL |  |
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| MAPKAPK5-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]
Gene Symbol : MAPKAPK5
Gene Name : Mitogen-activated protein kinase-activated protein kinase 5
Chromosome : CHR 12: 111,842,227-111,902,224
Locus : 12q24.12-q24.13
Alt. Genes : LRPPRC
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