This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients. [provided by RefSeq, May 2017]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MAPKBP1-20-RE | 20 (40 μL) | 200 μL |  |
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| MAPKBP1-20-OR | 20 (40 μL) | 200 μL |  |
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| MAPKBP1-20-GO | 20 (40 μL) | 200 μL |  |
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| MAPKBP1-20-GR | 20 (40 μL) | 200 μL |  |
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| MAPKBP1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients. [provided by RefSeq, May 2017]
Gene Symbol : MAPKBP1
Gene Name : Mitogen-activated protein kinase binding protein 1
Chromosome : CHR 15: 417,744,33-418,278,54
Locus : 15q15.1
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