MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MARCH1-20-RE | 20 (40 μL) | 200 μL |  |
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| MARCH1-20-OR | 20 (40 μL) | 200 μL |  |
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| MARCH1-20-GO | 20 (40 μL) | 200 μL |  |
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| MARCH1-20-GR | 20 (40 μL) | 200 μL |  |
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| MARCH1-20-AQ | 20 (40 μL) | 200 μL |  |
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MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010]
Gene Symbol : MARCH1
Gene Name : Membrane associated ring-CH-type finger 1
Chromosome : CHR 4: 164,384,049-163,524,297
Locus : 4q32.2-q32.3
Alt. Genes : OPTN
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