The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MBD1-20-RE | 20 (40 μL) | 200 μL |  |
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| MBD1-20-OR | 20 (40 μL) | 200 μL |  |
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| MBD1-20-GO | 20 (40 μL) | 200 μL |  |
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| MBD1-20-GR | 20 (40 μL) | 200 μL |  |
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| MBD1-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]
Gene Symbol : MBD1
Gene Name : Methyl-CpG binding domain protein 1
Chromosome : CHR 18: 502,817,73-502,668,81
Locus : 18q21.1
Alt. Genes : TRIM28
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