The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MDC1-20-RE | 20 (40 μL) | 200 μL |  |
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| MDC1-20-OR | 20 (40 μL) | 200 μL |  |
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| MDC1-20-GO | 20 (40 μL) | 200 μL |  |
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| MDC1-20-GR | 20 (40 μL) | 200 μL |  |
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| MDC1-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]
Gene Symbol : MDC1
Gene Name : Mediator of DNA damage checkpoint 1
Chromosome : CHR 6: 307,179,87-306,998,06
Locus : 6p21.33
Alt. Genes : G3BP1
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