This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MDM2-20-RE | 20 (40 μL) | 200 μL |  |
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| MDM2-20-OR | 20 (40 μL) | 200 μL |  |
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| MDM2-20-GO | 20 (40 μL) | 200 μL |  |
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| MDM2-20-GR | 20 (40 μL) | 200 μL |  |
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| MDM2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
Gene Symbol : MDM2
Gene Name : MDM2 proto-oncogene
Chromosome : CHR 12: 688,081,48-688,455,43
Locus : 12q15
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