Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MGMT-20-RE | 20 (40 μL) | 200 μL |  |
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| MGMT-20-OR | 20 (40 μL) | 200 μL |  |
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| MGMT-20-GO | 20 (40 μL) | 200 μL |  |
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| MGMT-20-GR | 20 (40 μL) | 200 μL |  |
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| MGMT-20-AQ | 20 (40 μL) | 200 μL |  |
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Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015]
Gene Symbol : MGMT
Gene Name : O-6-methylguanine-DNA methyltransferase
Chromosome : CHR 10: 129,467,183-129,770,982
Locus : 10q26.3
Alt. Genes : OPTN
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