The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MKL1-20-RE | 20 (40 μL) | 200 μL |  |
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| MKL1-20-OR | 20 (40 μL) | 200 μL |  |
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| MKL1-20-GO | 20 (40 μL) | 200 μL |  |
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| MKL1-20-GR | 20 (40 μL) | 200 μL |  |
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| MKL1-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Symbol : MKL1
Gene Name : Megakaryoblastic leukemia (translocation) 1
Chromosome : CHR 22: 406,367,18-404,102,80
Locus : 22q13.1-q13.2
Alt. Genes : RBM12
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