This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MLKL-20-RE | 20 (40 μL) | 200 μL |  |
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| MLKL-20-OR | 20 (40 μL) | 200 μL |  |
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| MLKL-20-GO | 20 (40 μL) | 200 μL |  |
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| MLKL-20-GR | 20 (40 μL) | 200 μL |  |
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| MLKL-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
Gene Symbol : MLKL
Gene Name : Mixed lineage kinase domain like pseudokinase
Chromosome : CHR 16: 747,011,86-746,718,54
Locus : 16q23.1
Alt. Genes : CEBPZ
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