This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MSH4-20-RE | 20 (40 μL) | 200 μL |  |
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| MSH4-20-OR | 20 (40 μL) | 200 μL |  |
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| MSH4-20-GO | 20 (40 μL) | 200 μL |  |
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| MSH4-20-GR | 20 (40 μL) | 200 μL |  |
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| MSH4-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011]
Gene Symbol : MSH4
Gene Name : MutS homolog 4
Chromosome : CHR 1: 757,968,70-759,132,37
Locus : 1p31.1
Alt. Genes : KIF20A
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