This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MTHFD2-20-RE | 20 (40 μL) | 200 μL |  |
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| MTHFD2-20-OR | 20 (40 μL) | 200 μL |  |
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| MTHFD2-20-GO | 20 (40 μL) | 200 μL |  |
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| MTHFD2-20-GR | 20 (40 μL) | 200 μL |  |
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| MTHFD2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009]
Gene Symbol : MTHFD2
Gene Name : Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Chromosome : CHR 2: 741,985,62-742,152,97
Locus : 2p13.1
Alt. Genes : FEM1B
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