The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MVB12B-20-RE | 20 (40 μL) | 200 μL |  |
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| MVB12B-20-OR | 20 (40 μL) | 200 μL |  |
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| MVB12B-20-GO | 20 (40 μL) | 200 μL |  |
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| MVB12B-20-GR | 20 (40 μL) | 200 μL |  |
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| MVB12B-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Symbol : MVB12B
Gene Name : Multivesicular body subunit 12B
Chromosome : CHR 9: 126,326,843-126,507,040
Locus : 9q33.3
Alt. Genes : RBM12
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