MXI1 FISH Probe

Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]


Gene Details
SKU Test Kits Buffer Dye Color Order Now
MXI1-20-RE 20 (40 μL) 200 μL color Request Pricing
MXI1-20-OR 20 (40 μL) 200 μL color Request Pricing
MXI1-20-GO 20 (40 μL) 200 μL color Request Pricing
MXI1-20-GR 20 (40 μL) 200 μL color Request Pricing
MXI1-20-AQ 20 (40 μL) 200 μL color Request Pricing

Gene Summary

Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol : MXI1

Gene Name : MAX interactor 1, dimerization protein

Chromosome : CHR 10: 110,207,604-110,287,364

Locus : 10q25.2

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