MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MYBPC3-20-RE | 20 (40 μL) | 200 μL |  |
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| MYBPC3-20-OR | 20 (40 μL) | 200 μL |  |
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| MYBPC3-20-GO | 20 (40 μL) | 200 μL |  |
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| MYBPC3-20-GR | 20 (40 μL) | 200 μL |  |
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| MYBPC3-20-AQ | 20 (40 μL) | 200 μL |  |
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MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
Gene Symbol : MYBPC3
Gene Name : Myosin binding protein C, cardiac
Chromosome : CHR 11: 473,527,01-473,314,05
Locus : 11p11.2
Alt. Genes : LRPPRC
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