This gene encodes an E3 ubiquitin-protein ligase and member of the PHR (Phr1/MYCBP2, highwire and RPM-1) family of proteins. The encoded protein plays a role in axon guidance and synapse formation in the developing nervous system. In mammalian cells, this protein regulates the cAMP and mTOR signaling pathways, and may additionally regulate autophagy. Reduced expression of this gene has been observed in acute lymphoblastic leukemia patients and a mutation in this gene has been identified in patients with a rare inherited vision defect. [provided by RefSeq, Mar 2017]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MYCBP2-20-RE | 20 (40 μL) | 200 μL |  |
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| MYCBP2-20-OR | 20 (40 μL) | 200 μL |  |
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| MYCBP2-20-GO | 20 (40 μL) | 200 μL |  |
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| MYCBP2-20-GR | 20 (40 μL) | 200 μL |  |
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| MYCBP2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes an E3 ubiquitin-protein ligase and member of the PHR (Phr1/MYCBP2, highwire and RPM-1) family of proteins. The encoded protein plays a role in axon guidance and synapse formation in the developing nervous system. In mammalian cells, this protein regulates the cAMP and mTOR signaling pathways, and may additionally regulate autophagy. Reduced expression of this gene has been observed in acute lymphoblastic leukemia patients and a mutation in this gene has been identified in patients with a rare inherited vision defect. [provided by RefSeq, Mar 2017]
Gene Symbol : MYCBP2
Gene Name : MYC binding protein 2, E3 ubiquitin protein ligase
Chromosome : CHR 13: 773,270,65-770,446,56
Locus : 13q22.3
Alt. Genes : SGK2
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