This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MYD88-20-RE | 20 (40 μL) | 200 μL |  |
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| MYD88-20-OR | 20 (40 μL) | 200 μL |  |
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| MYD88-20-GO | 20 (40 μL) | 200 μL |  |
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| MYD88-20-GR | 20 (40 μL) | 200 μL |  |
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| MYD88-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Gene Symbol : MYD88
Gene Name : Myeloid differentiation primary response 88
Chromosome : CHR 3: 381,384,77-381,430,21
Locus : 3p22.2
Alt. Genes : HIPK3
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