The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NAE1-20-RE | 20 (40 μL) | 200 μL |  |
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| NAE1-20-OR | 20 (40 μL) | 200 μL |  |
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| NAE1-20-GO | 20 (40 μL) | 200 μL |  |
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| NAE1-20-GR | 20 (40 μL) | 200 μL |  |
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| NAE1-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Symbol : NAE1
Gene Name : NEDD8 activating enzyme E1 subunit 1
Chromosome : CHR 16: 668,309,76-668,028,77
Locus : 16q22.1
Alt. Genes : ENAM
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