The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. This gene may regulate ureagenesis by altering NAG availability and, thereby, CPSI activity. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NAGS-20-RE | 20 (40 μL) | 200 μL |  |
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| NAGS-20-OR | 20 (40 μL) | 200 μL |  |
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| NAGS-20-GO | 20 (40 μL) | 200 μL |  |
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| NAGS-20-GR | 20 (40 μL) | 200 μL |  |
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| NAGS-20-AQ | 20 (40 μL) | 200 μL |  |
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The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. This gene may regulate ureagenesis by altering NAG availability and, thereby, CPSI activity. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia. [provided by RefSeq, Jul 2008]
Gene Symbol : NAGS
Gene Name : N-acetylglutamate synthase
Chromosome : CHR 17: 440,045,45-440,090,67
Locus : 17q21.31
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