This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NCOR1-20-RE | 20 (40 μL) | 200 μL |  |
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| NCOR1-20-OR | 20 (40 μL) | 200 μL |  |
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| NCOR1-20-GO | 20 (40 μL) | 200 μL |  |
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| NCOR1-20-GR | 20 (40 μL) | 200 μL |  |
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| NCOR1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
Gene Symbol : NCOR1
Gene Name : Nuclear receptor corepressor 1
Chromosome : CHR 17: 162,167,45-160,300,93
Locus : 17p12-p11.2
Alt. Genes : FAM13A
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