This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NDE1-20-RE | 20 (40 μL) | 200 μL |  |
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| NDE1-20-OR | 20 (40 μL) | 200 μL |  |
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| NDE1-20-GO | 20 (40 μL) | 200 μL |  |
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| NDE1-20-GR | 20 (40 μL) | 200 μL |  |
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| NDE1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Gene Symbol : NDE1
Gene Name : NudE neurodevelopment protein 1
Chromosome : CHR 16: 156,432,66-157,263,52
Locus : 16p13.11
Alt. Genes : KIF20A
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