The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NECAB3-20-RE | 20 (40 μL) | 200 μL |  |
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| NECAB3-20-OR | 20 (40 μL) | 200 μL |  |
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| NECAB3-20-GO | 20 (40 μL) | 200 μL |  |
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| NECAB3-20-GR | 20 (40 μL) | 200 μL |  |
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| NECAB3-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Symbol : NECAB3
Gene Name : N-terminal EF-hand calcium binding protein 3
Chromosome : CHR 20: 336,744,57-336,570,86
Locus : 20q11.22
Alt. Genes : CELA3A
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