This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NECTIN4-20-RE | 20 (40 μL) | 200 μL |  |
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| NECTIN4-20-OR | 20 (40 μL) | 200 μL |  |
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| NECTIN4-20-GO | 20 (40 μL) | 200 μL |  |
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| NECTIN4-20-GR | 20 (40 μL) | 200 μL |  |
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| NECTIN4-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]
Gene Symbol : NECTIN4
Gene Name : Nectin cell adhesion molecule 4
Chromosome : CHR 1: 161,089,594-161,070,990
Locus : 1q23.3
Alt. Genes : G3BP1
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