This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NEDD4-20-RE | 20 (40 μL) | 200 μL |  |
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| NEDD4-20-OR | 20 (40 μL) | 200 μL |  |
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| NEDD4-20-GO | 20 (40 μL) | 200 μL |  |
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| NEDD4-20-GR | 20 (40 μL) | 200 μL |  |
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| NEDD4-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]
Gene Symbol : NEDD4
Gene Name : Neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
Chromosome : CHR 15: 559,937,45-558,269,16
Locus : 15q21.3
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