Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NEFH-20-RE | 20 (40 μL) | 200 μL |  |
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| NEFH-20-OR | 20 (40 μL) | 200 μL |  |
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| NEFH-20-GO | 20 (40 μL) | 200 μL |  |
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| NEFH-20-GR | 20 (40 μL) | 200 μL |  |
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| NEFH-20-AQ | 20 (40 μL) | 200 μL |  |
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Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008]
Gene Symbol : NEFH
Gene Name : Neurofilament heavy
Chromosome : CHR 22: 294,801,91-294,912,89
Locus : 22q12.2
Alt. Genes : LRPPRC
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