The erythroid-specific protein encoded by this gene, and the ubiquitous transcription factor CP2, form the stage selector protein (SSP) complex, which is involved in preferential expression of the gamma-globin genes in fetal erythroid cells. Alternate use of an in-frame upstream non-AUG (CUG) translation initiation codon, and a downstream AUG codon, results in two isoforms. While the long isoform (22 kDa) acts as an activator, the short isoform (14 kDa) has been shown to repress gamma-globin gene expression. This gene is located in an intron of the FBXL13 gene on the opposite strand. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NFE4-20-RE | 20 (40 μL) | 200 μL |  |
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| NFE4-20-OR | 20 (40 μL) | 200 μL |  |
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| NFE4-20-GO | 20 (40 μL) | 200 μL |  |
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| NFE4-20-GR | 20 (40 μL) | 200 μL |  |
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| NFE4-20-AQ | 20 (40 μL) | 200 μL |  |
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The erythroid-specific protein encoded by this gene, and the ubiquitous transcription factor CP2, form the stage selector protein (SSP) complex, which is involved in preferential expression of the gamma-globin genes in fetal erythroid cells. Alternate use of an in-frame upstream non-AUG (CUG) translation initiation codon, and a downstream AUG codon, results in two isoforms. While the long isoform (22 kDa) acts as an activator, the short isoform (14 kDa) has been shown to repress gamma-globin gene expression. This gene is located in an intron of the FBXL13 gene on the opposite strand. [provided by RefSeq, Jul 2008]
Gene Symbol : NFE4
Gene Name : Nuclear factor, erythroid 4
Chromosome : CHR 7: 102,973,436-102,978,666
Locus : 7q22.1
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