This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NFKB2-20-RE | 20 (40 μL) | 200 μL |  |
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| NFKB2-20-OR | 20 (40 μL) | 200 μL |  |
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| NFKB2-20-GO | 20 (40 μL) | 200 μL |  |
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| NFKB2-20-GR | 20 (40 μL) | 200 μL |  |
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| NFKB2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Gene Symbol : NFKB2
Gene Name : Nuclear factor kappa B subunit 2
Chromosome : CHR 10: 102,394,109-102,402,528
Locus : 10q24.32
Alt. Genes : ZNF263
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