This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NFKBIA-20-RE | 20 (40 μL) | 200 μL |  |
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| NFKBIA-20-OR | 20 (40 μL) | 200 μL |  |
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| NFKBIA-20-GO | 20 (40 μL) | 200 μL |  |
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| NFKBIA-20-GR | 20 (40 μL) | 200 μL |  |
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| NFKBIA-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]
Gene Symbol : NFKBIA
Gene Name : NFKB inhibitor alpha
Chromosome : CHR 14: 354,047,53-354,015,09
Locus : 14q13.2
Alt. Genes : TRAP1
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