MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NFX1-20-RE | 20 (40 μL) | 200 μL |  |
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| NFX1-20-OR | 20 (40 μL) | 200 μL |  |
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| NFX1-20-GO | 20 (40 μL) | 200 μL |  |
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| NFX1-20-GR | 20 (40 μL) | 200 μL |  |
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| NFX1-20-AQ | 20 (40 μL) | 200 μL |  |
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MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq, Jul 2008]
Gene Symbol : NFX1
Gene Name : Nuclear transcription factor, X-box binding 1
Chromosome : CHR 9: 332,904,16-333,711,62
Locus : 9p13.3
Alt. Genes : FEM1B
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