The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects. [provided by RefSeq, Dec 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NKX2-8-20-RE | 20 (40 μL) | 200 μL |  |
Request Pricing |
| NKX2-8-20-OR | 20 (40 μL) | 200 μL |  |
Request Pricing |
| NKX2-8-20-GO | 20 (40 μL) | 200 μL |  |
Request Pricing |
| NKX2-8-20-GR | 20 (40 μL) | 200 μL |  |
Request Pricing |
| NKX2-8-20-AQ | 20 (40 μL) | 200 μL |  |
Request Pricing |
The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects. [provided by RefSeq, Dec 2015]
Gene Symbol : NKX2-8
Gene Name : NK2 homeobox 8
Chromosome : CHR 14: 365,826,13-365,800,10
Locus : 14q13.3
Alt. Genes : G3BP1
Lorem Ipsum is simply dummy text of the printing and typesetting industry.
Lorem Ipsum is simply dummy text of the printing and typesetting industry.